The alternative sigma factor katF (rpoS) regulates Salmonella virulence.
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چکیده
منابع مشابه
The PhoP/PhoQ two-component system stabilizes the alternative sigma factor RpoS in Salmonella enterica.
The sigma factor RpoS regulates the expression of many stress response genes and is required for virulence in several bacterial species. We now report that RpoS accumulates when Salmonella enterica serovar Typhimurium is growing logarithmically in media with low Mg(2+) concentrations. This process requires the two-component regulatory system PhoP/PhoQ, which is specifically activated in low Mg(...
متن کاملThe Sigma Factor RpoS Controls
Yanet Romero, Soledad Moreno, Josefina Guzmán, Guadalupe Espín and Daniel 4 Segura # 5 6 Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad 7 Nacional Autónoma de México, Cuernavaca, Morelos, México. 8 9 # Corresponding author. 10 Email: [email protected] 11 12 13 14 15 Mailing address: 16 Departamento de Microbiología Molecular, Instituto de Biotecnología UNAM 17...
متن کاملThe Salmonella typhimurium katF (rpoS) gene: cloning, nucleotide sequence, and regulation of spvR and spvABCD virulence plasmid genes.
The spv region of Salmonella virulence plasmids is essential for the development of a systemic infection in mice. Transcriptional activation of the spvABCD operon occurs during stationary growth phase and is mediated by the regulatory gene product SpvR. We have previously shown that expression of a spvRAB'-cat fusion in Escherichia coli was dependent on the katF (rpoS) locus which encodes an al...
متن کاملThe alternative sigma factor, sigmaE, is critically important for the virulence of Salmonella typhimurium.
In Escherichia coli, extracytoplasmic stress is partially controlled by the alternative sigma factor, RpoE (sigmaE). In response to environmental stress or alteration in the protein content of the cell envelope, sigmaE upregulates the expression of a number of genes, including htrA. It has been shown that htrA is required for intramacrophage survival and virulence in Salmonella typhimurium. To ...
متن کاملThe role of the sigma factor sigma S (KatF) in bacterial global regulation.
The protein encoded by katF (also known as nur, appR, csi-2, abrD, and rpoS in various alleles) has been biochemically confirmed to be an alternate sigma transcription factor and renamed sigma S. Its synthesis is controlled transcriptionally and posttranscriptionally by as yet undefined mechanisms that are active well into stationary phase. sigma S controls a regulon of 30 or more genes express...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1992
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.89.24.11978